This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis, and related autoimmune disorders.
Part 1 Epidemiology Chapter 1 Environmental Factors in the Epidemiology of Inflammatory Bowel DiseaseMorten H. Vatn Part 2 Immunobiology Chapter 2 The Intestinal Immune System in HealthPer Brandtzaeg Chapter 3 Understanding the Epithelial Barrier in Inflammatory Bowel DiseaseMatthew A. Odenwald, Jerrold R. Turner Chapter 4 Intestinal Microbiology and Ecology in Crohn's Disease and Ulcerative ColitisDirk Haller, Ludovica F. Butto Chapter 5 The Immune System in Inflammatory Bowel Disease: Antimicrobial PeptidesCharles L. Bevins Chapter 6 Vascular Responses to Intestinal InflammationD. Neil Granger, Norman R. Harris Chapter 7 Immunobiology of Human Dendritic Cells in Inflammatory Bowel DiseaseDaniel C. Baumgart Chapter 8 Immunobiology of T-Cells in Inflammatory Bowel DiseaseS. Snapper, D. Nguyen, A Biswas Chapter 9 Immunobiology of B cells in Inflammatory Bowel DiseaseAtsushi Mizoguchi, Atul K. Bhan Chapter 10 Immune Cells: Monocytes and MacrophagesGerhard Rogler Chapter 11 Immune Functions of Epithelial Cells in Inflammatory Bowel DiseaseEric L. Campbell, Sean P. Colgan Chapter 12 Autophagy and Endoplasmic Reticulum StressArthur Kaser Chapter 13 Matrix MetalloproteinasesPaolo Biancheri, Thomas T. MacDonald Chapter 14 Paradigm of T-cell Differentiation in Inflammatory Bowel DiseaseTakashi Nagaishi, Mamoru Watanabe Chapter 15 Pharmacological Intervention Studies Using Mouse Models of Chronic Intestinal InflammationCynthia Reinoso Webb, Matthew B. Grisham Chapter 16 Stem Cells and Organoids to Study Epithelial Cell Biology in Inflammatory Bowel DiseaseJorge O. Munera, James M. Wells Part 3 Diagnostic Approach Chapter 17 Enhanced EndoscopyRalf Kiesslich Chapter 18 Magnetic Resonance EnterographyPatrik Rogalla, Luis Guimaraes Chapter 19 Computed Tomography Enterography and Inflammatory Bowel DiseaseJ. G. Fletcher Chapter 20 Ultrasound in Inflammatory Bowel DiseaseA. Potthoff, C. Agne, M. Gebel Chapter 21 Laboratory Evaluation, Including Novel Diagnostic MarkersM. Flamant, X. Roblin Chapter 22 Pathology of Inflammatory Bowel DiseaseNora E. Joseph, Christopher R. Weber Chapter 23 Objective Assessment of Clinical Disease ActivityEdouard Louis, Catherine Van Kemseke, Catherine Reenaers Chapter 24 Objective Assessment of Endoscopic Disease Activity and Mucosal HealingBritt Christensen, David T. Rubin Chapter 25 Evaluation of Quality of Life in Crohn's disease and Ulcerative Colitis: What Is Health-Related Quality of Life?Katrine Carlsen, Pia Munkholm, Johan Burisch Chapter 26 Evaluation of Health Economics in Inflammatory Bowel DiseaseReena Khanna, Brian G. Feagan Part 4 Therapy Crohn's Disease Chapter 27 The Natural History of Inflammatory Bowel DiseaseCharles N. Bernstein Chapter 28 Conventional Medica Management of Crohn's Disease: SulfasalazineMiquel A. Gassull, Eduard Cabre Chapter 29 Steroid Therapy for Crohn's DiseaseA. Hillary Steinhart Chapter 30 Thiopurines in Crohns' disease Adi Lahat, Rami Eliakim Chapter 31 Conventional Medical Management of Crohn's Disease: MethotrexateGrace Harkin, Laurence Egan Chapter 32 Adalimumab for the Treatment of Crohn's Disease Remo Panaccione Chapter 33 Biologic Therapy of Crohn's Disease: CertolizumabAlessandro Armuzzi, Daniela Pugliese Chapter 34 Biologic Therapy of Crohn's Disease: InfliximabJan-Michael A. Klapproth, Gary R. Lichtenstein Chapter 35 Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease TreatmentPeter J. Mannon Chapter 36 Biologic Therapy of Crohn's Disease: Natalizumab, Vedolizumab and anti-MadCAMPieter Hindryckx, Geert D'Haens Chapter 37 Optimal Management of Fistulizing Crohn's DiseaseBruce Sands, Farhad Peerani Part 5 Therapy Ulcerative Colitis Chapter 38 Sulfasalazine and 5-Aminosalicylates for Ulcerative ColitisReena Khanna, John K. Marshall Chapter 39 Conventional Therapy of Ulcerative Colitis: CorticosteroidsKirstin Taylor, Peter R. Gibson Chapter 40 Medical Management of Ulcerative Colitis: Conventional Therapy--AzathioprineBarrett G. Levesque, Edward V. Loftus Chapter 41 Calcineurin Inhibitors in Ulcerative ColitisAndreas Fischer, Daniel C. Baumgart Chapter 42 Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: InfliximabMindy Lam, Brian Bressler Chapter 43 Biologic Therapy of Ulcerative Colitis: AdalimumabWalter Reinisch Chapter 44 Biologic Therapy of Ulcerative Colitis: GolimumabMark A. Samaan, Peter M. Irving Chapter 45 Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab beta 7), antiMadCAMSeverine Vermeire Chapter 46 Probiotics, Prebiotics, and Antibiotics in Inflammatory Bowel DiseasePaolo Gionchetti, Carlo Calabrese, Andrea Calafiore, Fernando Rizzello Chapter 47 Biosimiliars in the Treatment of Inflammatory Bowel DiseaseVivian W. Huang, Richard N. Fedorak Chapter 48 Step-up vs. Top-down Approach in Crohn's DiseaseChristine Y. Yu, Daniel W. Hommes Chapter 49 Leucocytapheresis Therapy of Inflammatory Bowel DiseaseTakanori Kanai Chapter 50 Surgical Management of Crohn's Disease and Ulcerative ColitisRobert R. Cima, John H. Pemberton Part 6 Extraintestinal Manifestations Chapter 51 Extraintestinal Manifestations: Autoimmune HepatitisMichael Manns, Nora Schweitzer Chapter 52 Primary Sclerosing CholangitisRoger W. Chapman, Kate D. Williamson Chapter 53 Autoimmune Pancreatitis and Other Organ InvolvementGo Kuwata, Terumi Kamisawa Chapter 54 Cutaneous and Oral Manifestations of Inflammatory Bowel DiseaseCaroline P. Allen, Susan M. Burge Chapter 55 Arthritis, Arthropathy and Osteoporosis in Inflammatory Bowel DiseaseAlistair Tindell, Hanna Johnsson, Iain B. McInnes Part 7 Nutrition Chapter 56 Nutrition in Inflammatory Bowel DiseaseAlan L. Buchman Part 8 Pregnancy, Family Planning and Pediatric Aspects Chapter 57 Pregnancy and Fertility in Inflammatory Bowel DiseaseRebecca Matro, Uma Mahadevan Chapter 58 Pediatric Aspects of Inflammatory Bowel DiseaseBrendan Boyle, Jeffrey S. Hyams Part 9 Surveillance and Prevention Chapter 59 Management and Prevention of Infectious Diseases in Irritable Bowel Disease PatientsKristine Macartney, Nigel Crawford Chapter 60 Incidence of Cancer and Screening in Inflammatory Bowel DiseaseJimmy K. Limdi, Francis A. Farraye Chapter 61 Inflammatory Bowel Diseases: How to Identify High Risk PatientsJacques Cosnes, Harry Sokol Part 10 Patient Perspective and Resources Chapter 62 Patient Perspective on Inflammatory Bowel DiseaseAyesha Williams, Marjorie Merrick Chapter 63 Patient Resources in Inflammatory Bowel DiseaseSanna Loennfors, Marco Greco
"This very complete book is an excellent resource on inflammatory bowel disease (IBD), discussing in detail all aspects of Crohn's disease and ulcerative colitis. ... This book is written for a very broad audience, from physicians and scientists to all healthcare personnel, who deal with IBD patients. ... All areas are covered in detail. Even though this is a large book, it is easy to read." (Henrique Fernandez, Doody's Book Reviews, September, 2017)