Pancreatitis: medical and surgical management provides gastroenterologists and GI surgeons, both fully qualified and in training, with a focused, evidence-based approach to the most exciting developments in the diagnosis and clinical management of pancreatitis. Focusing mainly on the rapidly changing and innovative medical and surgical strategies to manage the disease, new surgical procedures such as endoscopic biliary intervention and minimally invasive necrosectomy to exciting new medical therapies like Antiprotease, Lexipafant, probiotics and enzyme treatment are all discussed. Full colour throughout, with over 250 colour illustrations and with reference to the latest clinical guidelines from the AGA, ACG and UEGW at all times, it is an essential consultation tool for all those managing patients with this increasingly common condition.
List of contributors, vii 1 Epidemiology and genetics of chronic pancreatitis, 1 2A Pathobiology of the acinar cell in acute pancreatitis, 10 2B Locoregional pathophysiology in acute pancreatitis: pancreas and intestine, 19 2C Pathophysiology of systemic inflammatory response syndrome and multiorgan dysfunction syndrome in acute pancreatitis, 29 3 Diagnosis, prediction, and classification, 38 4 Medical treatment, 47 5 Nutritional treatment in acute pancreatitis, 55 6 Gallstone pancreatitis: diagnosis and treatment, 64 7 Treatment of local complications, 75 8 Treatment of systemic complications and organ failure, 85 9 Specific treatment for acute pancreatitis, 91 10 Sequelae of acute pancreatitis, 101 11 History of chronic pancreatitis, 113 12A Epidemiology and pathophysiology: epidemiology and risk factors, 118 12B Epidemiology and pathophysiology: genetic insights into pathogenesis, 126 12C Pancreatic stellate cells: what do they tell us about chronic pancreatitis?, 143 12D Autoimmune pancreatitis: an update, 152 12E Etiology and pathophysiology: tropical pancreatitis, 161 12F Mechanisms and pathways of pain in chronic pancreatitis, 169 13A Imaging of chronic pancreatitis, 179 13B Endoscopic ultrasonography in chronic pancreatitis, 188 14A Pancreatic enzyme replacement therapy (PERT), 195 14B Nutritional treatment: antioxidant treatment, 205 14C Pancreatogenic diabetes: etiology, implications, and management, 211 14D Nutrition without a pancreas: how does the gut do it?, 225 15A Endoscopic management of chronic pancreatitis, 233 15B Shocking and fragmenting pancreatic ductal stones, 245 15C Endoscopic management: celiac plexus blockade, 249 16A A brief history of modern surgery for chronic pancreatitis, 256 16B Surgery for chronic pancreatitis: indications and timing of surgery, 261 16C Chronic pancreatitis: surgical strategy in complicated diseases, 265 16D Surgery for chronic pancreatitis: pancreatic duct drainage procedures, 273 16E Surgical management: resection and drainage procedures, 279 16F The role of pancreatoduodenectomy in the management of chronic pancreatitis, 286 17A Total pancreatectomy and islet cell autotransplantation: patient selection, 295 17B Total pancreatectomy and islet cell autotransplantation: the science of islet cell preservation, from pancreas to liver, 299 17C Total pancreatectomy and islet cell autotransplantation: long-term assessment of graft function, 308 Index, 321
"Overall, this is an excellent book on all aspects of acute and chronic pancreatitis. It is concise yet comprehensive, written by well-known and well-published, credible authorities. It will be useful not just to the intended audience of gastroenterologists and GI surgeons, but also to all physicians involved in the care of patients with pancreatitis. Most books try to cover all aspects of this complex condition in a summary fashion, which is not possible. This book fills in the gaps by providing a focused, comprehensive review including latest evidence and guidelines. 5 Stars!" (Doody Enterprises July 2017) "This is a definitive and authoritative work that is quite manageable to read, understand and process. Because of that, a reader will return to it often, extending its benefits. Pancreatitis is challenging enough without having what this book provides. This excellent contribution has indeed refreshed and advanced my own knowledge-base by performing this review. Even the most seasoned practitioner can garner value in its pages, and again, return to it often" Charles M. Vollmer, Jr, MD, Professor of Surgery, University of Pennsylvania Perelman School of Medicine on behalf of HPB, Summer 2017